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Senior Scientist, Analytical Development

Umoja Biopharma

Umoja Biopharma

Seattle, WA, USA
Posted on Wednesday, January 31, 2024

Umoja Biopharma is a game-changing biotech start-up with locations in Seattle, WA and Louisville, CO, focused on transforming the treatment of cancer with a novel integrated immunotherapy platform. Our vision is to develop off-the-shelf therapies capable of treating any tumor, any time. We are a diverse and growing team working in brand-new facilities in downtown Seattle, Washington, and Louisville, Colorado, and we are looking for innovative thinkers who are excited by groundbreaking science and technology, and passionate about squaring up to the challenges inherent to cutting edge drug development. We are committed to the principles of Diversity Equity and Inclusion and strongly invite applications from enthusiastic individuals who share our commitment and help position Umoja as a leader in this front.

We at Umoja believe in the importance of stories; we are looking for great people to join our team to help us create more stories for ourselves, for you, and most importantly for patients and their families.

Umoja Biopharma – Your Body. Your Hope. Your Cure.

POSITION SUMMARY

Umoja Biopharma is seeking a Senior Scientist who can drive strategy, knowledge and deliverables related to understanding the potency of lentiviral drug products. This role will develop early- and late-stage potency methods for release of drug substance/product through new technology, staying current with regulatory guidance, troubleshooting, and generation of data packages to support regulatory submissions. The position will work closely with other functions to deliver qualified/validated QC release and characterization assays, generate associated documentation, and oversee transfer of methods internally or externally to a CMO/CRO. As a laboratory-based position within the technical operations organization, you will play a critical role in advancing Umoja’s pipeline and analytical development capabilities.


CORE ACCOUNTABILITIES

Specific responsibilities include:

  • Successful design, execution, analysis, and documentation of experiments to develop analytical methods and key data packages for lentiviral gene therapies.
  • Perform experiments to support analytical development and product characterization using advanced techniques including multicolor flow cytometry, ELISAs, Western blots, qPCR/dPCR, signal transduction and cytokine assays.
  • Oversee the qualification of analytical methods.
  • Author, review and approve technical documents including electronic notebook entries, standard operating procedures, test methods, technical reports, etc.
  • Present findings on method development and communicate interpretation and strategic plans related to the potency of our drug product to cross-functional teams.
  • Build analytical capabilities by bringing in new technology and equipment and hiring to support business objectives.
  • Foster good teamwork and communication. Build a reputation of excellence as an individual and as a team.

The successful candidate will have:

  • PhD in relevant field with >2 years of experience or BS/MS in Immunology or Molecular Biology with 8+/6+ years of experience, respectively; equivalent combination of education and experience will be considered
  • Hands-on experience with multicolor flow cytometry, cell-based assays, ELISAs, viral transduction, and qPCR/dPCR
  • Proven track record in cell-based method development, including experimental design, execution, and evaluation of data
  • Experience with trouble-shooting assays, creative problem-solving, and mentoring junior team members
  • Strong interest in innovative strategies for analysis and control of new modalities of cell and gene therapy
  • Ability to work in a fast-paced environment with broad responsibilities, meet deadlines, and prioritize work on multiple projects
  • Strong communication skills in technical writing and oral presentation. Respectful of others and open to new ideas.

Preferred Qualifications:

  • Ability to connect complex mechanisms of action for a gene therapy product to relevant analytical methods for potency
  • Experience qualifying and transferring analytical methods to a QC lab or CMO/CRO
  • Experience developing and qualifying potency methods according to ICH/USP guidelines
  • Experience developing processes that reduce execution and analysis time

Physical Requirements:

  • Ability to perform standard laboratory tasks with appropriate PPE
  • Perform physical tasks required to support laboratory work, including standing, walking, bending, kneeling, sitting, working with your hands in a biosafety cabinet, and occasionally moving materials up to 50 pounds
  • Ability to spend 6+ hours per day on the computer
  • Ability to work onsite most days of the week

Salary Range: $132,000 - $160,000

Benefits Offerings

Umoja Biopharma offers its employees competitive Medical, Dental, and Vision plans. Additionally, we offer Umojians access to a 401k plan through Fidelity, with a 100% match up to their first 6% deferral. Umoja also provides a generous Paid Time Off policy, employee commuter benefits, and cell phone stipend. For a full breakdown of our benefits offerings, please see the Benefits section of our website.