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Manufacturing Systems Engineer II

National Resilience

National Resilience

Software Engineering
west chester, oh, usa
Posted on Thursday, April 18, 2024

A career at Resilience is more than just a job – it’s an opportunity to change the future.

Resilience is a technology-focused biomanufacturing company that’s changing the way medicine is made. We’re building a sustainable network of high-tech, end-to-end manufacturing solutions to better withstand disruptive events, serve scientific discovery, and reach those in need.

For more information, please visit www.resilience.com

Position Summary & Responsibilities

Resilience is ushering in an era of “Biomanufacturing-as-a-Service” that we expect will displace in-house manufacturing as well as traditional contract manufacturing and development organizations (CDMOs). We see this as a paradigm shift in biomanufacturing akin to the IT industry’s adoption of Infrastructure-as-a-Service (IaaS) and Platform-as-a-Service (PaaS) that rendered obsolete corporate-owned/operated data centers or corporate servers co-located in hosting facilities.

As a Manufacturing Systems Engineer on Site Digital team you will bring to realization the Resilience digital and automation strategy across the manufacturing network. You’ll work with manufacturing, supply chain, quality and other key stakeholders to define the requirements for the next generation of manufacturing systems implementation. This includes leading the specification, configuration, administration, and maintenance of the manufacturing systems platforms. You will be a key collaborator within the Digital team to ensure integrations of all required systems is achieved. You'll need a strong sense of curiosity and growth mindset with a willingness to share and brainstorm new ways to do things.


  • Execute the Digital vision and strategy around manufacturing systems across the Resilience manufacturing network
  • Designs, specifies, and supports the manufacturing systems platforms, including implementing modifications to improve operational performance and product quality
  • Analyze, recommend, and implement manufacturing systems projects and enhancements across the Resilience manufacturing network, with focus on manufacturing execution, automation techniques and equipment integration.
  • Supports automation activities throughout technology transfer into the manufacturing network and provides continued support throughout manufacturing campaigns.
  • Develop, modify, and redline requirements/specifications related to integration of Biomanufacturing Automation platforms (e.g. equipment, software, P&ID, network topology, PFD)
  • Provide Subject Matter Expert support to Manufacturing, Technical Operations, and other departments for the design and operation of manufacturing systems platforms.
  • Coordinate with Digital Quality and Computer System Validation teams to generate and implement lifecycle documentation and validation protocols.
  • Build relationships and collaborate with Manufacturing, Technical Operations/Engineering, Manufacturing Science/Strategy & Technology, and Quality organizations


  • Experience in manufacturing operational technology (OT) environments
  • Extensive experience with manufacturing systems platforms, including in-depth knowledge of manufacturing technologies and systems at all levels of the ISA95 stack
  • Experience with Warehouse Execution System (WES) integrations to SCADA, ERP, LIMS and other manufacturing critical systems.
  • Tactical knowledge of digital automation systems such as Distributed Control System (DCS) and Programmable Logic Controller (PLC) configuration, field instrumentation installation and troubleshooting, as well as process control experience
  • Demonstrated ability to handle multiple competing priorities and projects in a fast-paced environment with a proven track record for delivering results on large, cross functional, global projects
  • Hands-on experience with IT change management across domains (security, software, network, hardware, etc.)
  • Fluid collaboration skills across business, IT, and external vendors/suppliers

Preferred Experience

  • 5+ years of experience in manufacturing or life sciences manufacturing operational technology (OT) environments
  • Bachelor of Science degree in an Engineering discipline. Preferred area of study: Chemical, Biomedical/Bio, Electrical, or Mechanical Engineering.
  • Experience with next generation MES platforms (e.g. Apprentice, Tulip) and applications
  • Experience with MES integrations to SCADA, ERP, LIMS and other manufacturing critical systems.
  • Fluency in supporting the digitization of manufacturing & engineering business process by bringing the IT know-how to business partners in Manufacturing and Technical Operations.
  • Builder mentality that seeks to produce innovation, agility, and velocity to support business-as-usual operations and new project implementation.

Resilience is an Equal Employment Opportunity Employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, disability status, physical or mental disability, genetic information, or characteristic, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state, and local laws. Requests for reasonable accommodation can be made at any stage of the recruitment process.

Resilience offers employees a robust total rewards program including equity, an annual cash bonus program, a 401(k) plan with a generous company match and our benefits package which is thoughtfully designed to support our employees with great healthcare (including medical, dental and vision), family building benefits, life and disability insurance, flexible time off, paid holidays, other paid leaves of absence, tuition reimbursement and support for caregiving needs. Our target base pay hiring range for this position is $90,000.00 - $135,000.00 per year. Actual base pay is dependent upon a number of factors, including but not limited to, the candidate’s geographical location, relevant experience, qualifications, skills and knowledge. Excited about Resilience and the biomanufacturing revolution? We encourage you to apply and start a conversation with one of our recruiters.