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Principal Scientist/Director, Cell Biology

Hexagon Bio

Hexagon Bio

Menlo Park, CA, USA
Posted on Saturday, February 17, 2024

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation medicines for human disease. We use data science, genomics, synthetic biology, and automation to discover potent, evolutionarily refined small molecules and their cognate targets from fungal genomes, and apply medicinal chemistry when needed to optimize these molecules into truly transformative medicines.

Location: Menlo Park, CA

Job description:

As a Director of the Cell Biology team, you will be part of a highly collaborative, interdisciplinary team, and will be responsible for the development of novel Antibody Drug Conjugates (ADCs), contributing to the advancement of groundbreaking therapeutic interventions. Your expertise in cancer biology, cell-based assays, and Antibody-Drug Conjugates (ADCs) will be essential to our mission of developing the next generation of medicines for human diseases. You will have the opportunity to set direction for and oversee the execution of ADC target validation and evaluation of payload strategies to advance innovative ADCs. We are seeking innovative team members inspired by our mission to work collaboratively in building the next-generation drug company. Candidates should demonstrate leadership, a passion for science, excellent communication skills, and strong collaborative skills to advance ADC projects forward.

The role is expected to be a mix of management, mentorship and laboratory work.

Key Responsibilities:

  • Lead, mentor and grow a team of high-performing cell biologists for ADC development
  • Oversee the design and execution of efficient in vitro experiments and in vivo studies to evaluate new ADCs with the goal of advancing candidate therapeutics
  • Provide ADC biology expertise including strategic, scientific and technical guidance for the company to build a robust pipeline of novel ADCs
  • Oversee the generation and analysis of experimental data to guide go/no-go decision-making processes
  • Effectively communicate findings and interpretation of results to multi-disciplinary teams
  • Build valuable relationships with consultants, advisors, and collaborators
  • May recruit junior scientists and research associates
  • Stay abreast of emerging technologies and scientific advancements for characterization of ADCs
  • Comply with company health and safety policies and general laboratory practices


  • PhD in Biology or related discipline with 8+ years of industrial experience.
  • Expertise with antibody-drug conjugates (ADCs)
  • Experience running and/or overseeing in vitro studies to evaluate human tumor cell function (e.g., cell culture, high-content imaging, and potency assays in primary and cell line cultures)
  • Understanding of tumor cancer models to evaluate ADCs
  • Strong desire to continue seeking new technological innovations
  • Management or mentorship experience in guiding a team of scientists in goal setting ensuring deliverables against timelines
  • Excellent analytical and problem-solving skills and the ability to propose innovative solutions.
  • Effective communication and collaboration skills, with the ability to work independently and as part of a multidisciplinary research team.
  • Evidence of scientific excellence and impact as illustrated by scientific publications and presentations.
  • Initiative and boldness to dive into a fast-paced new startup

What We Offer:

  • A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
  • “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
  • Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through TriNet, which offers additional voluntary benefits (pet insurance, accident insurance, home & auto insurance, and more).
  • Equity and a 401(k) plan.
  • Rapid career advancement for driven performers.
  • Access to scientific conferences all over the country throughout the year.
  • A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
  • Opportunities to engage with the Hexagon community through team-building events like our monthly Hexagon Happy Hour and holiday parties.

Additional Information:

The salary range is dependent on the level of Scientist that is hired (Principal Scientist or Director). The salary range for this full-time position is $190,000 to $250,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.