South San Francisco, CA, USA
Posted on Saturday, March 25, 2023
Do you want to be part of a brilliant team, using single-cell genomics to forge new paths in drug discovery? At Gordian, we combine unique large-scale in vivo perturbation screens with novel analysis approaches to identify therapeutic targets for complex diseases with unmet medical need.
- Perform general quality control and characterization of large single-cell genomics datasets (transcriptomic, epigenetic etc.)
- Apply secondary analysis workflows to single-cell genomics datasets and visualize results
- Streamline existing analysis code
- Test and implement state-of-the-art tools for genomics data analysis and visualization
- Assist in developing and coding novel analysis workflows for large-scale in vivo perturbation screens
- Work and communicate effectively with cross-functional data science, disease area and experimental platform teams
Experience in the following:
- Data science methods applied to large biological datasets: Experience manipulating and analyzing large biological datasets.
- Python: Strong proficiency in Python, data structures, and data science / ML related packages (e.g. Numpy, Pandas, SciPy, Scanpy).
- Data Visualization / Communication: Distilling analysis output into visualizations, tabulations, etc that effectively document and communicate results to those with and without a computational background.
- Linux / Cloud: Proficiencyworking in a linux cloud environment.
- Genomics data: Experience analyzing genomics data (RNA-seq or other).
Experience with single cell RNA-seq, and related packages in python/R is a plus. Experience in git and software engineering is also a plus.
Gordian has large-scale multidimensional single-cell genomics data across many cell types, with thousands of biological perturbations, in many species. Our data is unique, and making sense of it will require methodological analysis not only within each dataset, but across all of them. You’re excited to use and extend state-of-the-art tools for processing single cell transcriptomic data as well as assist in developing new analysis approaches and streamlining code. You will have the opportunity to learn how to analyze multiplexed in vivo perturbation data, integrate additional data modalities (including imaging, spatial transcriptomics, epigenetic sequencing) with transcriptomics, and perform comparative analyses of animal model and human patient data. Your work will happen in constant dialogue with both bioinformaticians and biologists. The tools and analysis workflows you build will be used by the whole company, and you’ll design and document them accordingly. You will be working on multiple projects at once, and seamless communication across departments is essential. You will need to pay attention to experimental descriptions and required outputs, and will be responsible for maintaining records and databases. By 3 months, you will have mastered Gordian’s compute environment and existing pipelines, have tested at least two external packages, streamlined two existing analysis workflows, and made contributions to at least one novel analysis.
Gordian Biotechnology is a therapeutics company focused on diseases of aging, the major unmet medical need of our generation.
Age-related diseases have complex causes that include interactions with the aged environment, and traditional ex vivo screening methods have failed to produce effective treatments. In contrast, Gordian’s platform delivers and tests hundreds of therapeutics in individual animals to generate the most relevant preclinical datasets, at scale.
Our mission is ambitious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability.
Team – Relying on each other begins with transparency. We set clear goals, visible to all, connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions with the bigger picture in mind. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help.
Extraordinary – Every day, we ask ourselves ‘could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return.
Like any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. Last year, in accordance with our unlimited vacation policy, each member took an average of 2.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by collaborative planning.
If this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. Dive deeper into our values here.
You truly want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness.
You have a history of successful execution, both in- and outside of your job description. You want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your work days with. You are motivated by the opportunity to learn and grow endlessly within a meritocratic and empowering company, with no limits to advancement based on formal credentials. Your continued growth is important to us, both in computational development and expansion of technical expertise.
Gordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in South San Francisco.
See more open positions at Gordian Biotechnology
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