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Associate Director, Immunology and Inflammation

Genesis Therapeutics

Genesis Therapeutics

San Diego, CA, USA
Posted on Saturday, May 18, 2024
Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our San Diego site is looking for a motivated and experienced immunologist to guide and execute on drug discovery efforts from hit identification to IND-enabling studies on small molecule projects. The successful candidate will have project leadership experience and an intimate understanding of biochemical and cellular assays and animal models of autoimmune disease indications.
This is a full-time position in a fast-paced biotech environment with a collegial group of highly productive colleagues working towards well-defined goals. Excellent medical and dental benefits, flexible work hours and vacation days make this an excellent opportunity to learn all aspects of biotech start-up in a supportive and inspiring environment.

What You Will Do - Key Responsibilities

  • Lead or co-lead small molecule drug discovery projects from hit identification through cellular validation, hit-to-lead and lead optimization into IND enabling studies
  • Design, develop and execute on biochemical and cellular assays together with a small group of associates to support short SAR cycles and fast compound progression
  • Identify CROs with suitable animal models to demonstrate in vivo PD and efficacy of compounds
  • Collaborate closely with multiple groups within the organization including Biochemistry, Cell Biology, Chemistry, DMPK, CADD, Structural Biology etc.

What you’ll bring

  • PhD in Immunology or a related field
  • 7+ years of biotech/pharma experience
  • Critical thinking, excellent analytical skills and focus in execution
  • Experience with immunological methods such as flow cytometry, cytokine analysis and primary cell assays
  • Deep understanding of disease biology in autoimmune and inflammatory indications
  • Track record of project leadership from hit generation to DC in a small molecule program
  • Managerial experience and excellent interpersonal/communication skills

We’d be thrilled if you have experience with

  • Translational models for autoimmune indications including whole blood assays
  • Biomarker identification and development
  • Experience with various -omics approaches and data mining

What we offer

  • Competitive Pay
  • Stock Option Eligibility
  • 401(k) Plan
  • Open PTO Policy
  • Paid Company Holidays
  • Free lunch and snacks at our offices
  • Health Care Plan, including Medical, Dental, and Vision, fully covered for the employees
Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.
Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets.
The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has two AI platform collaborations across a range of therapeutic areas: Eli Lilly (signed in 2022, with a $20M upfront payment and a $670M total deal size), and Genentech (signed in 2020).
We raised a $200M series B in August 2023, and have raised over $280M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures.
Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.
Finding the best talent is our top priority at Genesis Therapeutics. If you are interested in potential partnership on recruitment, please reach out to recruiting@genesistherapeutics.ai.