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Senior/Principal Research Associate, Preclinical & Translational Sciences

EGenesis

EGenesis

Cambridge, MA, USA
Posted on Friday, June 7, 2024
COMPANY MISSION
At eGenesis, we aspire to deliver safe and effective human transplantable cells, tissue and organs utilizing the latest advancements in genome editing.
POSITION SUMMARY
We are seeking an outstanding, highly motivated Senior Research Associate/Principal Research Associate to join our Development team. This role will support preclinical and translational science immunological assay optimization in the context of xenotransplantation. This position provides an excellent opportunity to help develop xenotransplantation products in an exciting and dynamic environment focused on cutting-edge molecular and cellular engineering technology.
In this role, you will be part of a team responsible for developing screening assays to inform patient selection as well as immune monitoring assays to be utilized during transplantation. The role will involve significant cell culture work, in vitro and ex vivo analyses with porcine, non-human primate, and human cells and biosamples. The ideal candidate will have strong experience in immunological assay development, preferably using Incucyte® and flow cytometry techniques, and will play a critical role in driving our xenotransplantation organ programs forward.

PRIMARY RESPONSIBILITIES

  • Design, execute, and analyze immunological experiments to support pre-transplant screening in the context of xenotransplantation.
  • Develop and optimize a complement-dependent cytotoxicity (CDC) assay to be used as a routine pre-transplant screening tool.
  • Develop and optimize assays to assess immune responses, including multi-color flow cytometry, Incucyte®, ELISA, and other techniques.
  • Coordinate sequencing efforts for transcriptomics analysis for preclinical/translational studies in collaboration with the computational biology team.
  • Perform and assist with primary cell derivations for different organ programs.
  • Collaborate with cross-functional teams (analytical development, preclinical, translational, computational biology) to advance projects.
  • Interpret experimental data and present findings to internal and external stakeholders.
  • Maintain accurate and detailed laboratory records in compliance with regulatory standards.
  • Contribute to the preparation of research reports and regulatory submissions.

QUALIFICATIONS

  • Bachelor’s or Master’s degree in Immunology, Biology, or a related field.
  • 4-6 years of hands-on experience in immunology within the biotech industry.
  • Proficiency in immunological techniques, including flow cytometry, ELISAs, cell culture, and molecular biology methods.
  • Strong understanding of the Incucyte® system, multi-color flow cytometry, and primary cell culture.
  • Sample management, including collection, processing, storage, and documentation.
  • Excellent written and verbal communication skills.
  • Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
  • Demonstrated ability to manage multiple projects and meet deadlines.
  • Strong understanding of the CDC immune pathway is a plus.
  • Experience with transcriptomics is a plus.
  • Experience with the R platform is a plus.