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Associate Scientist II - Scientist I, Next Generation Sequencing

Chroma Medicine

Chroma Medicine

Cambridge, MA, USA
Posted on Tuesday, June 4, 2024

Chroma Medicine is pioneering a new class of genomic medicines that harness epigenetics, nature’s innate mechanism for gene regulation, revolutionizing the treatment of genetically driven diseases. As a start-up genomic medicine company with world-leading scientific founders, strong investment backing including Newpath Partners and Atlas Venture, and experienced leadership, Chroma is positioned to be the leader in epigenetic editing.

The epigenome is nature’s gatekeeper for gene expression, governing cell phenotype and function by precisely controlling gene activity without changing the underlying DNA sequence. Building on groundbreaking research from the world’s foremost genomic medicine experts, Chroma Medicine is working at the cutting edge of precision genomics, building an entirely new class of therapeutics to achieve unparalleled control of gene expression.

We are hiring at our Boston, Massachusetts site, offering a unique opportunity to be part of our foundational Chroma team.


We are seeking a highly motivated and resilient scientist with expertise in molecular biology, NGS and assay development. The ideal candidate will have a track record of success in hands-on experience of NGS library prep, sequencing, and scaling up NGS assays to generate high-quality data consistently in biotech or pharmaceutical industry. The position will work closely with diverse and cross-funtional teams to support sequencing projects, so good organizational and communication skills are a must.


  • Work both independently and as part of collaborative team to execute assays that support development activities, project goals, and platform development
  • Independently run and optimize NGS workflows to streamline the process by scaling up with automation and establishing SOPs
  • Deeply understand and troubleshoot NGS experiments to ensure assay robustness and generation of high-quality data.
  • Meet established timelines, maintain accurate records of work, and present data at team, departmental and company-wide meetings.
  • Participate in lab organization and inventory
  • Contribute to data tracking and management using ELN and LIMS


  • PhD or B.S./M.S. with 8+ years of relevant experience with a degree in molecular biology, biochemistry, bioengineering, genetics, or related disciplines.
  • Experience in the pharmaceutical or biotechnology industry performing NGS assays and workflows
  • Experience in NGS assay development and implementation, such as methyl-seq, RNA-seq, amplicon sequencing, single-cell sequencing, etc.
  • Extensive hands-on experience with Illumina short-read sequencers.
  • Proficiency in molecular biology techniques including DNA/RNA extraction, PCR, RT-qPCR,
  • Team-oriented mindset with ability to work both independently and collaboratively.
  • Passionate, adaptable, and keen on working in the fast-paced biotech startup space.
  • Detail oriented and self-motivated, with excellent problem solving and organizational skills.


  • Experience with Oxford Nanopore or PacBio sequencing technologies
  • Experience working with external partners and computational biologists
  • Deep knowledge of epigenetics, chromatin biology, gene editing, and/or transcriptional regulation a plus.
  • Experience executing IND-enabling studies

Chroma Medicine is an equal opportunity employer, providing equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Chroma Medicine complies with applicable state and local laws governing nondiscrimination in employment.

COVID-19 Vaccination Policy: All Chroma Medicine team members must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemptions for medical or sincerely held religious beliefs will be considered.