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Director, Total Rewards & HR Ops

4D Molecular Therapeutics

4D Molecular Therapeutics

People & HR, Operations
Emeryville, CA, USA
Posted on Friday, May 31, 2024

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. Agencies must be expressly engaged by the 4DMT Talent Acquisition team on any requisition. Agencies reaching out directly to hiring managers will not be tolerated and doing so may impact your ability to work with 4DMT in the future.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators:

• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine


We are excited to have an experienced Director, Total Rewards and HR Operations join our amazing HR team! This role is critical to our success and will have the responsibility of executing a comprehensive Total Rewards strategy, including compensation, bonus, equity, and benefits programs. This role will also be responsible for enhancing and helping us scale HR Operations across the company. This role will remain current on industry trends, best practices, compliance and drive operational excellence and innovation in all areas of responsibility.


Total Rewards ~60% Time

  • Design, lead, and administer compensation and benefits programs in connection with applicable processes across the organization at 4DMT.
  • Provide ongoing strategic and data-driven insights around the Total Rewards program for our growing organization.
  • Support VP, HR with Compensation Committee work throughout the year.
  • Partner with Talent Acquisition to maintain a thoughtful, equitable, and competitive process for the growing organization within our compensation guidelines.
  • Provide strategic leadership, data driven proposals for the benefits design, selection, broker management, and analysis of cost savings yet competitive offering in the biotech talent market.
  • Oversee benefits and compensation day to day operations, and provide support to HR leaders and people managers throughout the company.
  • Lead cyclical compensation tasks that include, but are not limited to; market benchmarking reviews, budget management, compensation planning, recognition programs, offer review, retention exercises, and continued analyses.
  • Manage the design, development, implementation, communication and administration of benefits and leave of absence programs.
  • Collaborate and partner with leadership to understand the challenges related to compensation, benefits, and other reward programs and key issues in attracting, motivating and retaining high quality, diverse talent.
  • Educate and empower employees navigating life events, leave of absences and be an escalation point for benefit or compensation questions.
  • Participate in the selection and management of all vendors, brokers, and administrative partners.
  • Validate the effectiveness of compensation and benefit programs, ensuring market competitiveness and business objectives are achieved.
  • Proactively monitor and remain current on internal and external industry trends, relevant pay and benefits related legislation and compliance.

HR Operations ~40% Time

  • Lead, develop, improve, implement, and oversee HR Operations processes and administration.
  • Ensure that HR processes are developed and performed in compliance with all legal and organizational requirements, standards, and procedures.
  • Partner with HR team to implement new HRIS tool(s).
  • Oversee and improve our HR workforce analytics ensuring data integrity across all relevant metrics and produce valuable business insights for leadership.
  • Optimize HRIS to meet ongoing workforce and compliance requirements and create opportunities for automation, reporting, and reduction of manual processes.
  • Oversee and manage HR compliance including leading HR audits, documentation, and testing of key controls, and ensuring internal policies and processes support compliance requirements.
  • Research and recommend advancements in HR technology, in partnership with HR team, IT and organizational strategy and practices.
  • This position will remain well-informed on industry trends, will be active within the professional HR community where possible, and will challenge the organization to continually develop best practices within HR and business operations.
  • Other duties as assigned.



  • Bachelor’s degree; Master’s degree in relevant field is a plus

Experience and skills:

  • 10+ years of relevant HR experience in total rewards and operations.
  • Requires experience working in a publicly traded company and within the Life Sciences industry.
  • Requires experience with preparation of materials for the Compensation Committee meetings.
  • In depth expertise designing innovative compensation and benefits models across different employee segments and have experience with executive compensation program design and governance.
  • Required excellent skills in developing effective presentations in PowerPoint.
  • Driven self-starter with a strong attention to detail.
  • Proven project management, delegation, collaboration, and influence skills.
  • Effective interpersonal skills to collaborate effectively and build strong relationships.
  • Experience leading direct reports and teams.
  • Knowledge of Federal, California, other state and local legal considerations related to compensation and benefits administration.
  • Ability to work and communicate with employees at many levels across diverse cultures.
  • Excellent judgment in handling confidential, sensitive information.
  • Experience with HRIS (preferably ADP), Microsoft Suite tools (including Outlook, PowerPoint, Word, and Excel), benefits administration and compensation tools.

Base salary compensation range:

National Range: $179,000/yr - $225,000/yr

Bay Area Range: $212,000/yr - $240,000/yr

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities