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Sr. HR Business Partner

4D Molecular Therapeutics

4D Molecular Therapeutics

People & HR
Emeryville, CA, USA
Posted on Wednesday, May 29, 2024

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. Agencies must be expressly engaged by the 4DMT Talent Acquisition team on any requisition. Agencies reaching out directly to hiring managers will not be tolerated and doing so may impact your ability to work with 4DMT in the future.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators:

• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine


We are excited to have an experienced Senior HR Business Partner join our amazing HR team at 4D Molecular Therapeutics! This role is critical to our continued success and will be responsible for partnering with employees and managers to execute on 4D’s people strategies in areas of organizational development, change management, employee engagement, employee relations, and performance management. In this role, you will support, consult, advise, coach, influence, innovate and challenge our managers and individual contributors on people-related issues. This role will partner with the Director, HRBP, employees and leaders to further support and drive HR initiatives to improve the effectiveness of the organization as whole, provide recommendations that will enhance management capability, employee retention, and positively impact overall organizational performance.

*This is a hybrid role. Seeking Bay Area based candidates.*


  • Partner with Director, HRBP to develop and implement effective HR policies and practices that will support the strategic growth of the business
  • Coach and consult line managers in all issues regarding people management, HR practices, policy, employment law, employment relations, change and performance management, etc.
  • Educate, coach, and partner with managers on performance management and employee development and career goals
  • Provide timely information and/or education for all levels of a company on HR issues
  • Participate and support management in organizational assessment, talent gap analysis, organization structure to turn business strategies into action
  • Facilitate and support the calibration process with HR and leadership.Support all Learning & Development initiatives and strategy to work on value-added programs in areas of training, development, career mobility, and job performance for our employees
  • Work in partnership with Director HRBP on projects related to employee engagement and retention
  • Consult with key organizational stakeholders to identify and diagnose organizational problems and design and help implement innovative and sustainable solutions
  • Consult with Director, HBRP and Leadership to identify strategies that support the desired organizational culture across 4D while also connecting to specific needs of individual functional areas
  • Collaborate with the HR team to champion and accelerate a culture of excellence in which people feel engaged and inspired to deliver top business results
  • Identify opportunities and help shape strategies and plans to address gaps
  • Support the DEI efforts and strategy at the company
  • Help drive adoption and consistency of HR programs with special emphasis on Diversity and Inclusions initiatives
  • Stay current on trends in the HR field to ensure solutions are progressive and relevant
  • Participate and collaborate with HR team in the continual development of HR programs, such as recruiting, retention, compensation, benefits, and other programs
  • Perform other duties as necessary and assigned



  • Bachelor’s degree


  • Requires 8+ years of HR experience, with at least 3 years in a Business Partner role
  • Requires experience working in a publicly traded company and within the Life Sciences industry.


  • Sound business acumen
  • Requires excellent skills in developing effective presentations in PowerPoint.
  • Excellent judgment in handling confidential, sensitive information.
  • Effective interpersonal skills to collaborate effectively and build strong relationships
  • Self-driven with the ability to prioritize and multitask
  • Ability to work and communicate with employees at many levels across diverse cultures
  • Excellent judgment in handling confidential, sensitive information
  • Excellent overall communication, writing and organizational skills
  • Extensive knowledge of Federal, California, other state and local legal regulations related to employment and HR policies.
  • Experience with HRIS (preferably ADP), Microsoft Suite tools (including Outlook, PowerPoint, Word, and Excel), benefits administration and compensation tools.

Base salary compensation range:

Bay Area Range: $143,000/yr - $176,000/yr

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities