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Sr. Director, Program Management

4D Molecular Therapeutics

4D Molecular Therapeutics

Emeryville, CA, USA
Posted on Thursday, May 23, 2024

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. Agencies must be expressly engaged by the 4DMT Talent Acquisition team on any requisition. Agencies reaching out directly to hiring managers will not be tolerated and doing so may impact your ability to work with 4DMT in the future.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators:

• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine


4DMT is seeking a Sr. Director, Program Management to join its team. This role will be responsible for ensuring the progress and success of the clinical stage assets at 4DMT. The ideal candidate will have prior drug development experience in complex biologics and a deep understanding of the requirements in all stages of drug development.


  • Lead cross-functional teams to develop and execute clinical program strategy
  • Drive strategic and tactical planning, program budget preparation and management
  • Prepare accurate program updates for the Executive Team
  • Assess program needs and guide operational decisions
  • Drive planning for key drug development stage-gate decision points
  • Identify project risks and facilitate mitigation strategies
  • Ensure communication and alignment across departments
  • Present information and respond to questions from the Executive Leadership Team and Board of Directors
  • Support the establishment and maintenance of best practices and knowledge management databases
  • Participate in system and process improvements



  • Bachelor’s degree in life sciences or a relevant field (Advanced degree preferred)


  • 15+ years experience managing global complex cross-functional projects/programs in the biopharmaceutical industry
  • 6+ years of management experience
  • Sound knowledge of integrated drug development process
  • Experience with gene or cell therapy programs preferred
  • Experience in ophthalmology or pulmonology therapeutic areas desirable
  • Excellent interpersonal and communication skills
  • Strong project management skills (PMP certification a plus)


  • Proficient in the Microsoft suite of programs, including but not limited to, MS Project
  • Ability to guide and motivate a team towards achieving set goals. It also includes decision-making skills.
  • Effective verbal and written communication skills are essential for conveying project goals and strategies to team members and stakeholders.
  • The ability to identify, analyze, and find solutions to problems that may arise during the project lifecycle.
  • The ability to prioritize tasks, manage time effectively, and meet deadlines.
  • The ability to manage relationships with stakeholders, understand their needs and expectations, and ensure their satisfaction is crucial.

Compensation range:

Bay Area Range: $265,000/yr - $314,000/yr

Outside Bay Area Range: $250,000/yr - $293,000/yr

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities