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Staff Scientist- Chemist

10X Genomics

10X Genomics

Pleasanton, CA, USA
Posted on Thursday, May 23, 2024

About the role:

10x is looking for an outstanding staff scientist to join the Process Development team and be responsible for development and transfer of new chemistries from concept to full implementation in a commercial manufacturing facility. This position works cross-functionally with the R&D Chemistry, Microfluidics, Molecular Biology, and Engineering teams, as well as, QC, Production, and Supply Chain. Candidates must have a broad working knowledge of organic, polymer, oligonucleotide, surface, other NGS related chemistries and associated analytical methods, and be able to creatively translate those principles to establish production processes at commercial scale. The successful applicant will have exceptional attention to detail and the ability to meticulously execute and analyze highly complex experiments. Previous industry experience successfully commercializing and supporting similar processes is essential.

Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contribution.

What you will be doing:

  • Develop, optimize, validate and implement a broad range of chemistry-based production processes from R&D into Manufacturing.
  • Integration of these chemistries into various microarray or fluidic handling mechanisms.
  • Develop a deep understanding of the interplay between chemistry, microfluidics, production processes, and molecular biology to assist in identifying the root cause of product deviations, troubleshoot them, and identify solutions.
  • Experimentation to develop a deep understanding of the underlying reaction mechanisms and interactions, cause and effect, failure modes, guard band studies and optimization using DOE methodologies.
  • Establish development plans to ensure robust manufacturing processes through use of FMEA and risk assessment, guardbanding, material selection, and QC strategy.
  • Identify and optimize any compounding factors, such a temperature, environment, workflow, pressures, reagent concentrations that could impact the resulting product.
  • Scale up and develop alternative production processes to meet demand as 10x Genomics continues to grow.
  • Develop process QC methods to ensure processes are in control.
  • Independently troubleshoot and resolve issues related to manufacturing processes, QC, and incoming material quality.
  • Implement statistical process control tools.
  • Verification that the output manufactured products meet all requirements.
  • Communicate and present results clearly and contribute data for making critical design decisions through accurate record of experimental details, documentation, and presentations.

Minimum Requirements:

  • PhD in Organic Chemistry, Polymer Chemistry, Surface Chemistry, Analytical Chemistry, Process Chemistry or related field
  • 5+ years of relevant experience in biotechnology or life science related industry.
  • Strong process development experience demonstrating control of manufacturing processes through appropriate Process Design and QC methods.
  • Ability to integrate a broad range of scientific and engineering disciplines.
  • Ability to design meaningful experiments and in depth analysis of results. Experience using statistical tools, such as JMP, is beneficial.
  • Ability to develop, validate and transfer processes to manufacturing or OEM vendors.
  • Excellent collaboration and communication skills.
  • Ability to travel internationally as needed.
  • Desire to be part of a rapidly evolving organization, with a compelling technology, and taking products and processes to the next level.

#LI-MH1 #on-site

Below is the base pay range for this full time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. Your 10x recruiter can share more about the Company’s total compensation package during the hiring process.

Pay Range
$170,000$230,000 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.